Research Article
BibTex RIS Cite

Fabrication and characterization of PCL/ZnO-NP nanocomposite for wound dressing applications

Year 2018, Volume: 1 Issue: 2, 54 - 58, 20.12.2018

Abstract

Nanotechnology has a critical role in biotechnology and medicine with aiming to develop portable, low cost, safe and practical technologies. One of these technologies includes construction of three dimensional biomimetic nanofiber scaffolds with using electrospinning method. Nanofibers have started to be used with the development of nanotechnology in tissue engineering because of its similarity to natural human tissues. The architecture of original extracellular matrix at nanoscale level can be mimicked by these scaffolds. Meanwhile, metal nanoparticles are also used in tissue engineering because of their unique features such as optical, electronic, catalytic, and antibacterial. Zinc oxide (ZnO) is a transition metal oxide and it has good catalytic, electrical, photochemical, optical, antibacterial, enhanced cell proliferation and wound healing properties. Zn ion also acts as regulator for auto debridement and keratinocyte migration, both of which are essential for wound repair. Polycaprolactone (PCL) which is biocompatible and biodegradable synthetic polymer used as biomaterial for various biomedical applications such as tissue engineering scaffolds and wound dressings. In the present study, zinc oxides nanoparticles (ZnO-NPs) synthesized by microwave irradiation were used for the fabrication of PCL/ZnO-NP nanocomposite via electrospinning method. The effects of the ZnO nanoparticle concentration on the fiber diameter and fiber morphology were investigated using a scanning electron microscope (SEM). The presence of ZnO-NPs in the structure was determined by X-ray diffraction (XRD). It was observed that the average diameter of nanofibers was below micrometers. Overall results showed that PCL/ZnO-NP nanocomposite were found to be suitable for wound dressing applications.

References

  • Augustine R, Malik HN, Singhal DK, Mukherjee A, Malakar D, Kalarikkal N, Thomas S 2014. Electrospun polycaprolactone/ZnO nanocomposite membranes as biomaterials with antibacterial and cell adhesion properties. Journal of Polymer Research, 21(347): 1-18.
  • Faal Hamedani N, Farzaneh F 2006. Synthesis of ZnO Nanocrystals with Hexagonal (Wurtzite) Structure in Water Using Microwave Irradiation, Journal of Sciences, Islamic Republic of Iran 17(3): 231-234.
  • Gomes SR, Rodrigues G, Martins GG, Roberto MA, Mafra M, Henriques CMR, Silva JC 2015. In vitro and in vivo evaluation of electrospun nanofibers of PCL, chitosan and gelatin: A comparative study, Mater. Sci. Eng. C 46:348–358.
  • Hasanpoor M, Aliofkhazraei M, Delavari H 2015. Microwave-assisted synthesis of zinc oxide nanoparticles, Procedia Materials Science 11:320 – 325.
  • Król A, Pomastowski P, Rafińska K, Railean-Plugaru V, Buszewski B 2017. Zinc oxide nanoparticles: Synthesis, antiseptic activity and toxicity mechanism, Advances in Colloid and Interface Science 249:37–52.
  • Lansdown ABG, Mirastschijski U, Stubbs N, Scanlon E, Agren MS 2007. Zinc in wound healing: theoretical, experimental, and clinical aspects, Wound Repair Regen. 15(1): 2-16.
  • Lee SH, Lee R, Kim Y, Kim M 2012. Toxic Response of Zinc Oxide Nanoparticles in Human Epidermal Keratinocyte HaCaT Cells, Toxicol. Environ. Health. Sci 4(1): 14-18.
  • Liu M, Duan X, Li Y, Yang D, Long Y 2017. Electrospun nanofibers for wound healing. Materials Science and Engineering C 76: 1413–1423.
  • Mogoşanu GD, Grumezescu AM 2014. Natural and synthetic polymers for wounds and burns dressing. International Journal of Pharmaceutics 463: 127– 136.
  • Münchow EA, Albuquerque MTP, Zero B, Kamocki K, Piva E, Gregory RL, Bottino MC 2015. Development and characterization of novel ZnO-loaded electrospun membranes for periodontal regeneration. Dental Materials 31: 1038–1051.
  • Premanathan M, Karthikeyan K, Jeyasubramanian K, Manivannan G 2011. Selective toxicity of ZnO nanoparticles toward Gram-positive bacteria and cancer cells by apoptosis through lipid peroxidation, Nanomedicine: Nanotechnology, Biology, and Medicine 7: 184–192.
  • Shoja M, Shameli K, Ahmad MB, Kalalntarı K 2015. Preparation, characterization and antibacterial properties of Polycaprolactone/ZnO microcomposites. Digest Journal of Nanomaterials and Biostructures 10(1): 169-178.
  • Toduka Y, Toyooka T, Ibuki Y 2012. Flow Cytometric Evaluation of Nanoparticles Using Side-Scattered Light and Reactive Oxygen Species-Mediated Fluorescence−Correlation with Genotoxicity, Environ. Sci. Technol.46: 7629−7636.
  • Wei Q, Xu F, Xu X, Geng X, Ye L, Zhang A, Feng Z, 2016. The multifunctional wound dressing with core–shell structured fibers prepared by coaxial electrospinning. Front. Mater. Sci. 10(2): 113–121.
  • Xue J, Shi R, Niu Y, Gong M, Coates P, Crawford A, Chen D, Tian W, Zhang L 2015. Fabrication of drug-loaded anti-infective guided tissue regeneration membrane with adjustable biodegradation property, Colloids and Surfaces B: Biointerfaces 135: 846–854.
  • Zhang G, Shen X, Yang Y 2011. Facile Synthesis of Monodisperse Porous ZnO Spheres by a Soluble Starch-Assisted Method and Their Photocatalytic Activity, The Journal of Physical Chemistry C 115: 7145–7152.
Year 2018, Volume: 1 Issue: 2, 54 - 58, 20.12.2018

Abstract

References

  • Augustine R, Malik HN, Singhal DK, Mukherjee A, Malakar D, Kalarikkal N, Thomas S 2014. Electrospun polycaprolactone/ZnO nanocomposite membranes as biomaterials with antibacterial and cell adhesion properties. Journal of Polymer Research, 21(347): 1-18.
  • Faal Hamedani N, Farzaneh F 2006. Synthesis of ZnO Nanocrystals with Hexagonal (Wurtzite) Structure in Water Using Microwave Irradiation, Journal of Sciences, Islamic Republic of Iran 17(3): 231-234.
  • Gomes SR, Rodrigues G, Martins GG, Roberto MA, Mafra M, Henriques CMR, Silva JC 2015. In vitro and in vivo evaluation of electrospun nanofibers of PCL, chitosan and gelatin: A comparative study, Mater. Sci. Eng. C 46:348–358.
  • Hasanpoor M, Aliofkhazraei M, Delavari H 2015. Microwave-assisted synthesis of zinc oxide nanoparticles, Procedia Materials Science 11:320 – 325.
  • Król A, Pomastowski P, Rafińska K, Railean-Plugaru V, Buszewski B 2017. Zinc oxide nanoparticles: Synthesis, antiseptic activity and toxicity mechanism, Advances in Colloid and Interface Science 249:37–52.
  • Lansdown ABG, Mirastschijski U, Stubbs N, Scanlon E, Agren MS 2007. Zinc in wound healing: theoretical, experimental, and clinical aspects, Wound Repair Regen. 15(1): 2-16.
  • Lee SH, Lee R, Kim Y, Kim M 2012. Toxic Response of Zinc Oxide Nanoparticles in Human Epidermal Keratinocyte HaCaT Cells, Toxicol. Environ. Health. Sci 4(1): 14-18.
  • Liu M, Duan X, Li Y, Yang D, Long Y 2017. Electrospun nanofibers for wound healing. Materials Science and Engineering C 76: 1413–1423.
  • Mogoşanu GD, Grumezescu AM 2014. Natural and synthetic polymers for wounds and burns dressing. International Journal of Pharmaceutics 463: 127– 136.
  • Münchow EA, Albuquerque MTP, Zero B, Kamocki K, Piva E, Gregory RL, Bottino MC 2015. Development and characterization of novel ZnO-loaded electrospun membranes for periodontal regeneration. Dental Materials 31: 1038–1051.
  • Premanathan M, Karthikeyan K, Jeyasubramanian K, Manivannan G 2011. Selective toxicity of ZnO nanoparticles toward Gram-positive bacteria and cancer cells by apoptosis through lipid peroxidation, Nanomedicine: Nanotechnology, Biology, and Medicine 7: 184–192.
  • Shoja M, Shameli K, Ahmad MB, Kalalntarı K 2015. Preparation, characterization and antibacterial properties of Polycaprolactone/ZnO microcomposites. Digest Journal of Nanomaterials and Biostructures 10(1): 169-178.
  • Toduka Y, Toyooka T, Ibuki Y 2012. Flow Cytometric Evaluation of Nanoparticles Using Side-Scattered Light and Reactive Oxygen Species-Mediated Fluorescence−Correlation with Genotoxicity, Environ. Sci. Technol.46: 7629−7636.
  • Wei Q, Xu F, Xu X, Geng X, Ye L, Zhang A, Feng Z, 2016. The multifunctional wound dressing with core–shell structured fibers prepared by coaxial electrospinning. Front. Mater. Sci. 10(2): 113–121.
  • Xue J, Shi R, Niu Y, Gong M, Coates P, Crawford A, Chen D, Tian W, Zhang L 2015. Fabrication of drug-loaded anti-infective guided tissue regeneration membrane with adjustable biodegradation property, Colloids and Surfaces B: Biointerfaces 135: 846–854.
  • Zhang G, Shen X, Yang Y 2011. Facile Synthesis of Monodisperse Porous ZnO Spheres by a Soluble Starch-Assisted Method and Their Photocatalytic Activity, The Journal of Physical Chemistry C 115: 7145–7152.
There are 16 citations in total.

Details

Primary Language English
Subjects Chemical Engineering
Journal Section Research Articles
Authors

Alev Akbaş

Melek Erol Taygun

Sadriye Küçükbayrak

Publication Date December 20, 2018
Acceptance Date December 15, 2018
Published in Issue Year 2018 Volume: 1 Issue: 2

Cite

APA Akbaş, A., Erol Taygun, M., & Küçükbayrak, S. (2018). Fabrication and characterization of PCL/ZnO-NP nanocomposite for wound dressing applications. Eurasian Journal of Biological and Chemical Sciences, 1(2), 54-58.
AMA Akbaş A, Erol Taygun M, Küçükbayrak S. Fabrication and characterization of PCL/ZnO-NP nanocomposite for wound dressing applications. Eurasian J. Bio. Chem. Sci. December 2018;1(2):54-58.
Chicago Akbaş, Alev, Melek Erol Taygun, and Sadriye Küçükbayrak. “Fabrication and Characterization of PCL/ZnO-NP Nanocomposite for Wound Dressing Applications”. Eurasian Journal of Biological and Chemical Sciences 1, no. 2 (December 2018): 54-58.
EndNote Akbaş A, Erol Taygun M, Küçükbayrak S (December 1, 2018) Fabrication and characterization of PCL/ZnO-NP nanocomposite for wound dressing applications. Eurasian Journal of Biological and Chemical Sciences 1 2 54–58.
IEEE A. Akbaş, M. Erol Taygun, and S. Küçükbayrak, “Fabrication and characterization of PCL/ZnO-NP nanocomposite for wound dressing applications”, Eurasian J. Bio. Chem. Sci., vol. 1, no. 2, pp. 54–58, 2018.
ISNAD Akbaş, Alev et al. “Fabrication and Characterization of PCL/ZnO-NP Nanocomposite for Wound Dressing Applications”. Eurasian Journal of Biological and Chemical Sciences 1/2 (December 2018), 54-58.
JAMA Akbaş A, Erol Taygun M, Küçükbayrak S. Fabrication and characterization of PCL/ZnO-NP nanocomposite for wound dressing applications. Eurasian J. Bio. Chem. Sci. 2018;1:54–58.
MLA Akbaş, Alev et al. “Fabrication and Characterization of PCL/ZnO-NP Nanocomposite for Wound Dressing Applications”. Eurasian Journal of Biological and Chemical Sciences, vol. 1, no. 2, 2018, pp. 54-58.
Vancouver Akbaş A, Erol Taygun M, Küçükbayrak S. Fabrication and characterization of PCL/ZnO-NP nanocomposite for wound dressing applications. Eurasian J. Bio. Chem. Sci. 2018;1(2):54-8.